Influenza2010: Zoonotic Influenza and Human Health: Part-A
نویسندگان
چکیده
Since the first appearance of the pandemic (H1N1) 2009 virus many efforts have been made to monitor the changes of the virus at molecular level with the aim to early detect mutations which could alter its pathogenicity. Some mutations have been observed more frequently in viruses that caused severe or fatal infections than in viruses involved in mild infections. Among these, the most common seems to be the amino acid substitution D222G (or D222E or D222N) in the HA1 sequence. However, to better assess the association of such mutation with pandemic virus pathogenicity a large set of data is required, in addition to other experimental studies.
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